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Mesenchymal to Epithelial Transition Mediated by CDH1 Promotes Spontaneous Reprogramming of Male Germline Stem Cells to Pluripotency

Cultured spermatogonial stem cells (GSCs) can spontaneously form pluripotent cells in certain culture conditions. However, GSC reprogramming is a rare event that is largely unexplained. We show GSCs have high expression of mesenchymal to epithelial transition (MET) suppressors resulting in a develop...

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Principais autores: Junhui An, Yu Zheng, Christina Tenenhaus Dann
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-02-01
coleção:Stem Cell Reports
Assuntos:
male germline stem cell
reprogramming
Mesenchymal to epithelial transition
CDH1
ZEB1
TGFb signalling
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221367111630296X
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