Application of patient-derived organotypic tumor spheroids to guide combination immunotherapy for advanced HCC: a case report

BackgroundPredicting response to combination immunotherapy in advanced hepatocellular carcinoma (HCC) remains a challenge. The patient-derived organotypic tumor spheroid (PDOTS) model, which may preserve aspects of the tumor immune microenvironment, represents a potentially promising tool for person...

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Principais autores:	Fu-Yi Wang, Li-Long Zhu, Cheng Ji, Jie Deng, Lu Han, Fei Song, Zhong Chen
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2026-06-01
叢編:	Frontiers in Oncology
主題:	combination immunotherapy drug sensitivity testing hepatocellular carcinoma (HCC) patient-derived organotypic tumor spheroids (PDOTS) personalized medicine tumor microenvironment
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1744326/full
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