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Structurally targeted mutagenesis identifies key residues supporting α-synuclein misfolding in multiple system atrophy

Background Multiple system atrophy (MSA) and Parkinson's disease (PD) are caused by misfolded α-synuclein spreading throughout the central nervous system. While familial PD is linked to several α-synuclein mutations, no mutations are associated with MSA. We previously showed that the familial PD mut...

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Principais autores: Patricia M Reis, Sara AM Holec, Chimere Ezeiruaku, Matthew P Frost, Christine K Brown, Samantha L Liu, Steven H Olson, Amanda L. Woerman
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publishing 2024-12-01
Serier:Journal of Parkinson’s Disease
Online adgang:https://doi.org/10.3233/JPD-240296
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