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Genetic algorithm-based personalized models of human cardiac action potential.

We present a novel modification of genetic algorithm (GA) which determines personalized parameters of cardiomyocyte electrophysiology model based on set of experimental human action potential (AP) recorded at different heart rates. In order to find the steady state solution, the optimized algorithm...

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Autors principals: Dmitrii Smirnov, Andrey Pikunov, Roman Syunyaev, Ruslan Deviatiiarov, Oleg Gusev, Kedar Aras, Anna Gams, Aaron Koppel, Igor R Efimov
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2020-01-01
Col·lecció:PLoS ONE
Accés en línia:https://doi.org/10.1371/journal.pone.0231695
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