Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells

Abstract Background Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). Accordingly, long term cultures of isolated OSE cells undergo in...

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Auteurs principaux:	Ulises Urzúa, Sandra Ampuero, Katherine F. Roby, Garrison A. Owens, David J. Munroe
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2016-10-01
Collection:	BMC Genomics
Sujets:	Ovarian cancer model Preneoplasia Mouse ovarian surface epithelium Transcriptome Genome Aneuploidy
Accès en ligne:	http://link.springer.com/article/10.1186/s12864-016-3068-5
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