Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages

Global increases in the prevalence of antimicrobial resistance highlight the urgent need for novel strategies to combat infectious diseases. Recent studies suggest that host metabolic pathways play a key role in host control of intracellular bacterial pathogens. In this study we explored the potenti...

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Autores principales:	Cassandra L. R. van Doorn, Gina K. Schouten, Suzanne van Veen, Kimberley V. Walburg, Jeroen J. Esselink, Matthias T. Heemskerk, Frank Vrieling, Tom H. M. Ottenhoff
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-09-01
Colección:	Frontiers in Immunology
Materias:	host-directed therapy dichloroacetate (DCA) pyruvate dehydrogenase kinase (PDK) Salmonella typhimurium primary human macrophages
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.739938/full
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