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Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease

Background & Aims: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly expressed in the liver and is implicated in hepatic...

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Autori principali: Aline Mello, Ming-Fo Hsu, Shinichiro Koike, Bryan Chu, Jeff Cheng, Jun Yang, Christophe Morisseau, Natalie J. Torok, Bruce D. Hammock, Fawaz G. Haj
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021-01-01
Serie:Cellular and Molecular Gastroenterology and Hepatology
Soggetti:
Soluble Epoxide Hydrolase
Alcohol-Associated Liver Disease
Hepatocyte
Injury
Steatosis
Inflammation
Accesso online:http://www.sciencedirect.com/science/article/pii/S2352345X20301624
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