An Effective Sodium-Dependent Glucose Transporter 2 Inhibition, Canagliflozin, Prevents Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats

Background: The aim of the study was to investigate the protective effect of canagliflozin (CANA) on myocardial metabolism and heart under stress overload and to further explore its possible molecular mechanism.Methods: High-salt diet was used to induce heart failure with preserved ejection fraction...

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Bibliografiset tiedot

Päätekijät:	Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Zhongli Wang, Tingting Zhang, Jianlong Zhai, Yifang Guo
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2022-03-01
Sarja:	Frontiers in Pharmacology
Aiheet:	heart failure with preserved ejection fraction hypertension myocardial hypertrophy canagliflozin fibrosis metabolism
Linkit:	https://www.frontiersin.org/articles/10.3389/fphar.2022.856386/full
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