ATM immunohistochemistry as an effective screening method for POLE variants among endometrial carcinomas lacking mismatch repair deficiency and p53 abnormalities

Abstract The molecular classification of endometrial carcinomas (ECs) is now integrated into clinical practice. However, identification of polymerase‐ε (POLE) variants remains reliant on DNA sequencing, which limits broader implementation. Given the strong prognostic value of pathogenic POLE mutatio...

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Detalhes bibliográficos

Principais autores:	Xinyi Huang, Yingmei Wang, Wenjing Ni, Luyang Zhong, Yang Qin, Shujun Zeng, Hong Xu, Yuling Qu, Peizhen Hu, Jing Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-03-01
coleção:	The Journal of Pathology: Clinical Research
Assuntos:	endometrial carcinoma ataxia telangiectasia mutated (ATM) immunohistochemistry polymerase‐ε (POLE) no specific molecular profile (NSMP)
Acesso em linha:	https://doi.org/10.1002/2056-4538.70086
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