Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out.

CRISPR gene therapy holds the potential to cure a variety of genetic diseases by causing a targeted DNA break, which is repaired by host DNA damage responses. One option to introduce precise gene corrections is via the homology-directed repair (HDR) pathway. The problem in utilizing this pathway is...

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Egile Nagusiak:	Danny Wilbie, Selma Eising, Vicky Amo-Addae, Johanna Walther, Esmeralda Bosman, Zhiyong Lei, Olivier G de Jong, Jan J Molenaar, Enrico Mastrobattista
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Public Library of Science (PLoS) 2025-01-01
Saila:	PLoS ONE
Sarrera elektronikoa:	https://doi.org/10.1371/journal.pone.0332617
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