CRISPR/Cas9 mediated FGFR2 down-regulation alleviatespremature closure of cranial suture in an Apert syndromemouse model

Apert syndrome (AS) is characterized by synostosis of coronal sutures, midfacial hypoplasia,abnormity of brain, syndactyly of hands and feet. Majority of AS is caused by gain-of-function mutation of fibro‐blast growth factor receptor 2 (FGFR2). To date, the treatment of AS is surgical correction for...

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Principais autores:	Luo Fengtao, Xie Yangli, Li Can, Tan Qiaoyan, Du Xiaolan, Chen Lin
格式:	Artigo
語言:	Chinês
出版:	Lanzhou University Press 2021-06-01
叢編:	生物医学转化
主題:	craniosynostosis apert syndrome fgfr2 crispr/cas9 gene editing
在線閱讀:	http://swyxzh.ijournals.cn/swyxzh/article/html/20210210?st=article_issue
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