Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons

Abstract Background Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants in the TCF4 gene have been identified as susceptibility factors for schizophrenia. It remains largely unknown, which b...

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Bibliografski detalji

Glavni autori:	Matthias Jung, Benjamin M. Häberle, Tristan Tschaikowsky, Marie-Theres Wittmann, Elli-Anna Balta, Vivien-Charlott Stadler, Christiane Zweier, Arnd Dörfler, Christian Johannes Gloeckner, D. Chichung Lie
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-03-01
Serija:	Molecular Autism
Teme:	Pitt-Hopkins syndrome Schizophrenia TCF4 Neurodevelopment
Online pristup:	http://link.springer.com/article/10.1186/s13229-018-0200-1
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