Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

HIV-1 Gag selects and packages a dimeric, unspliced viral RNA in the context of a large excess of cytosolic human RNAs. As Gag assembles on the plasma membrane, the HIV-1 genome is enriched relative to cellular RNAs by an unknown mechanism. We used a minimal system consisting of purified RNAs, recom...

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Detalhes bibliográficos

Principais autores:	Lars-Anders Carlson, Yun Bai, Sarah C Keane, Jennifer A Doudna, James H Hurley
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2016-06-01
Colecção:	eLife
Assuntos:	HIV-1 virus assembly viral genome packaging SHAPE giant unilamellar vesicles
Acesso em linha:	https://elifesciences.org/articles/14663
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