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Colchicine causes prenatal cell toxicity and increases tetraploid risk

Abstract Background Colchicine is a clinical medicine used for relief from gout and familial Mediterranean fever. Because of its toxic effects, intravenous injection of colchicine has been banned, but it is still widely administered orally. We assayed the toxic effects of colchicine in cultured prim...

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Principais autores: Ding Wang, Yingjun Xie, Minyi Yan, Qianying Pan, Yi Liang, Xiaofang Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-11-01
Serier:BMC Pharmacology and Toxicology
Fag:
Colchicine
Chorionic villus cells
Amniotic fluid cells
Cell cycle arrest
Tetraploid generation
Online adgang:http://link.springer.com/article/10.1186/s40360-019-0365-z
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