Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice

Sepsis and septic shock are associated with high mortality and are considered one of the major public health concerns. The onset of sepsis is known as a hyper-inflammatory state that contributes to organ failure and mortality. Recent findings suggest a potential role of two non-receptor protein tyro...

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Detalhes bibliográficos

Principais autores:	Gustavo Ferreira Alves, Eleonora Aimaretti, Giacomo Einaudi, Raffaella Mastrocola, Junior Garcia de Oliveira, Debora Collotta, Elisa Porchietto, Manuela Aragno, Carlo Cifani, Regina Sordi, Christoph Thiemermann, Daniel Fernandes, Massimo Collino
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
coleção:	Frontiers in Immunology
Assuntos:	sepsis NLRP3 inflammasome inflammation Focal adhesion kinase (FAK) proline-rich tyrosine kinase 2 (PYK2)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.837180/full
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