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Contribution of thalamo-cortico-limbic circuits to remifentanil-induced hyperalgesia (RIH) and the analgesic effects of electroacupuncture on RIH

Remifentanil is an ultrashort-acting opioid receptor agonist that has the greatest advantage in clinical analgesia but often induces hyperalgesia. The underlying mechanisms of remifentanil-induced hyperalgesia (RIH) remain unclear. Here, we report that exposure of remifentanil to rats induces an ele...

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Principais autores: Si-Qing Cai, Yue Tian, Zi‑Xian Zhang, Hong-Yan Zhao, Jie Cai, Min Li, Guo-Gang Xing
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:Brain Research Bulletin
Fag:
Remifentanil-induced hyperalgesia
Pain-related thalamo-cortico-limbic circuits
In vivo multi-channel electrophysiology
Chemogenetics
Optogenetics
Electroacupuncture
Online adgang:http://www.sciencedirect.com/science/article/pii/S0361923025003946
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