LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter

Highlights 1. LncRNA KCNQ1OT1 is upregulated, while EIF2B5 is downregulated in OC tissues and cells. 2. Knockdown of KCNQ1OT1 represses OC cell proliferation and metastasis. 3. KCNQ1OT1 decreases EIF2B5 expression by recruiting DNA methyltransferases into EIF2B5 promoter, thereby promoting OC progre...

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Autors principals:	Si-Li He, Ya-Ling Chen, Qi-Hua Chen, Qi Tian, Shui-Jing Yi
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2022-09-01
Col·lecció:	Molecular Medicine
Matèries:	Ovarian cancer lncRNA KCNQ1OT1 EIF2B5 Methylation Proliferation Metastasis
Accés en línia:	https://doi.org/10.1186/s10020-022-00521-5
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