Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

Abstract Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the $$S/F$$ S / F ratio. Because of the ceiling effect in oxyhaemoglob...

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Autori principali:	Maaike C. Swets, Steven Kerr, James Scott-Brown, Adam B. Brown, Rishi Gupta, Jonathan E. Millar, Enti Spata, Fiona McCurrach, Andrew D. Bretherick, Annemarie Docherty, David Harrison, Kathy Rowan, Neil Young, ISARIC4C Investigators, Geert H. Groeneveld, Jake Dunning, Jonathan S. Nguyen-Van-Tam, Peter Openshaw, Peter W. Horby, Ewen Harrison, Natalie Staplin, Malcolm G. Semple, Nazir Lone, J. Kenneth Baillie
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2023-11-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-023-42205-6
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