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Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma

Abstract Background Lysosomes are closely linked to autophagic activity, which plays a vital role in pancreatic ductal adenocarcinoma (PDAC) biology. The survival of PDAC patients is still poor, and the identification of novel genetic factors for prognosis and treatment is highly required to prevent...

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Автори: Youngil Koh, Hyemin Kim, So Young Joo, Seulki Song, Young Hoon Choi, Hyung Rae Kim, Byul Moon, Jamin Byun, Junshik Hong, Dong-Yeop Shin, Solip Park, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Daechan Park, Se-Hoon Lee, Jin-Young Jang, Hyunsook Lee, Jung-Ae Kim, Sung-Soo Yoon, Joo Kyung Park
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2023-10-01
Серія:Journal of Translational Medicine
Предмети:
Pancreatic ductal adenocarcinoma
Lysosomal dysfunction
Autophagy
Germline variants
Genetic sequencing
Онлайн доступ:https://doi.org/10.1186/s12967-023-04549-x
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