E3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production

ABSTRACT Membrane-associated RING-CH-type finger (MARCH) proteins, a class of E3 ubiquitin ligases, have been reported to be involved in the infection of multiple viruses and the regulation of type I interferon (IFN) production. However, the specific role and mechanisms by which MARCH proteins influ...

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Autors principals:	Chenxi Li, Chenyang Tang, Xiqian Liu, Ying Liu, Linjie Zhang, Jing Shi, Qingyu Li, Mingan Sun, Yanhua Li
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-04-01
Col·lecció:	mBio
Matèries:	Japanese encephalitis virus MARCH5 ubiquitination MAVS RLR signaling pathway
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.00208-25
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