Human Keratinocytes Inhibit CD4⁺ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints

Human skin protects the body against infection and injury. This protection involves immune and epithelial cells, but their interactions remain largely unknown. Here, we show that cultured epidermal keratinocytes inhibit allogenic CD4⁺ T-cell proliferation under both normal and inflammator...

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Principais autores:	Guillaume Mestrallet, Frédéric Auvré, Chantal Schenowitz, Edgardo D. Carosella, Joel LeMaoult, Michèle T. Martin, Nathalie Rouas-Freiss, Nicolas O. Fortunel
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-06-01
Series:	Cells
Assuntos:	skin immunity human keratinocytes immunomodulation HLA-G1 PD-L1 TGFB1
Acceso en liña:	https://www.mdpi.com/2073-4409/10/6/1438
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