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Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

Abstract Background Tumor resistance represents a major challenge in the current oncology landscape. Asparagine endopeptidase (AEP) overexpression correlates with worse prognosis and reduced overall survival in most human solid tumors. However, the underlying mechanisms of the connection between AEP...

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Egile Nagusiak: Macarena Morillo-Huesca, Ignacio G. López-Cepero, Ryan Conesa-Bakkali, Mercedes Tomé, Colin Watts, Pablo Huertas, Gema Moreno-Bueno, Raúl V. Durán, Jonathan Martínez-Fábregas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2025-02-01
Saila:Journal of Experimental & Clinical Cancer Research
Sarrera elektronikoa:https://doi.org/10.1186/s13046-025-03334-6
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