Activation of STING requires palmitoylation at the Golgi
STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases.
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2016-06-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/ncomms11932 |
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