Successful tocilizumab-based combination therapy for a case of rapidly progressive adult deep morphea with multiple antiphospholipid antibodies: a case report and literature review

BackgroundLocalized Scleroderma (LoS), particularly aggressive subtypes such as Deep Morphea (morphea profunda), is a rare chronic autoimmune fibrosing disorder that can extend into the subcutaneous tissue, fascia, and muscle. These deep forms carry a high risk of functional impairment. Tocilizumab...

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Autori principali:	Ruohan Yu, Lina Zhang, Sheng-Guang Li, Jing Zhang, Ji Li, Yadan Zou, Ting Long, Yanfeng Zhang, Guanjun Yue
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-02-01
Serie:	Frontiers in Immunology
Soggetti:	antiphospholipid antibodies case report deep morphea interleukin-6 (IL-6) localized scleroderma tocilizumab
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1764835/full
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