Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency

Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific antibody responses, comprises a heterogeneous patient population in terms of clinical presentation and underlying etiology. The diagnosis is reg...

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Bibliografiska uppgifter

Huvudupphov:	Pauline van Schouwenburg, Susanne Unger, Kathryn J. Payne, Fabian M. P. Kaiser, Ingrid Pico-Knijnenburg, Jens Pfeiffer, Oliver Hausmann, David Friedmann, Michelle Erbel, Maximilian Seidl, David van Zessen, Andrew P. Stubbs, Mirjam van der Burg, Klaus Warnatz
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2022-10-01
Serie:	Frontiers in Immunology
Ämnen:	germinal center common variable immunodeficiency (CVID) B-cell differentiation BCR repertoire analysis secondary lymphoid organs (SLO) plasma cell differentiation
Länkar:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.959002/full
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