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Synthesis and Antitumor Activity of Staurosporine Derivatives

Twenty-four derivatives of staurosporine were synthesized by modification at the 3′- N , 3- and 7-positions. Of these compounds, 16 were synthesized for the first time and their structures were determined by NMR spectroscopy, ECD, and HRESIMS. Their inhibitory activities against seven tumor cell lin...

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Autores principales: Gang Li, Dan Wu, Yanchao Xu, Wenwen He, Dongyang Wang, Weiming Zhu, Liping Wang
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publishing 2022-06-01
Colección:Natural Product Communications
Acceso en línea:https://doi.org/10.1177/1934578X221103036
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