mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors

Efficient photodynamic therapy with meta-tetra(hydroxyphenyl)chlorine requires the application of specific nanoformulations. mTHPC liposomal formulation (Foslip®) demonstrated favorable pharmacokinetics properties. However, rapid liposomes destruction in circulation and rapid mTHPC release impedes F...

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Auteurs principaux:	Marie Millard, Ilya Yakavets, Max Piffoux, Amanda Brun, Florence Gazeau, Jean-Michel Guigner, Jordane Jasniewski, Henri-Pierre Lassalle, Claire Wilhelm, Lina Bezdetnaya
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis Group 2018-01-01
Collection:	Drug Delivery
Sujets:	mthpc photodynamic therapy multicellular tumor spheroid extracellular vesicles nanocarriers
Accès en ligne:	http://dx.doi.org/10.1080/10717544.2018.1513609
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