RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila.
Ribosomal DNA (rDNA), which encodes ribosomal RNA, is an essential but unstable genomic element due to its tandemly repeated nature. rDNA's repetitive nature causes spontaneous intrachromatid recombination, leading to copy number (CN) reduction, which must be counteracted by a mechanism that recover...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
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Public Library of Science (PLoS)
2024-05-01
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| Serier: | PLoS Genetics |
| Online adgang: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011136&type=printable |
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