Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 differentially perturb cellular homeostasis remains incomplete...

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Autori principali:	Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw, Rakshith Rakshith, Nitish Kamble, Vikram Holla, Ravi Yadav, Pramod Kumar Pal, Indrani Datta
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-02-01
Serie:	Cells
Soggetti:	LRRK2 GTPase domain mutation membrane lipid homeostasis Parkinson’s disease Rab8A/Rab10 phosphorylation cholesterol trafficking
Accesso online:	https://www.mdpi.com/2073-4409/15/4/342
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