Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

Abstract Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, generation, and cultivation time represent important challenges for their usage. Therefore, th...

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Autori principali:	M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering, Mircea Gabriel Stoleriu, Wilhelm Bertrams, Bernd Schmeck, Ali Önder Yildirim, Ursula Rauen, Timo Wille, Mareike Lehmann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-02-01
Serie:	Respiratory Research
Soggetti:	Human precision-cut lung slices (hPCLS) 3R Long-term cold storage Tissue preservation Fibrosis Human lung models
Accesso online:	https://doi.org/10.1186/s12931-025-03132-w
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