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Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I

Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®)...

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Detalhes bibliográficos
Corporate Authors:	Silva, Vera L. M., Silva, Artur M. S.
Formato:	Livro
Idioma:	Inglês
Publicado em:	MDPI - Multidisciplinary Digital Publishing Institute 2022
Assuntos:	bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general bic Book Industry Communication::P Mathematics & science::PN Chemistry bic Book Industry Communication::P Mathematics & science::PN Chemistry::PNN Organic chemistry pyrazolopyridopyridazine dione N-aminopyrazolopyrrolopyridine dione luminol photoluminescence pyrazole coumarin antimicrobial hydrazone biofilm Staphylococcus aureus S. epidermidis MRSA pyrazolyl-ureas pyrazole nucleus protein kinase inhibitors anti-inflammatory agents anticancer agents anti-pathogens agents nitrated pyrazoles-based energetic salts synthesis high energy density material insensitivity amination 4-halopyrazole Buchwald-Hartwig coupling Pd(dba)2 CuI mediated coupling aliphatic amine X-ray pyrazolate coinage metals metallacycles M06-2x pyrazolyl-s-triazine Fe(III) self-assembly Hirshfeld antimicrobial activity pyrazoles styrylpyrazoles biological activity organic synthesis reactivity homocoupling bipyrazole transition-metal catalysts metal–organic frameworks 1,3-dipolar cycloadditions 2,3-dihydropyrazolo[1,2-a]pyrazoles copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC) azomethine imines ynones bis(pyrazol-1-yl)alkanes carboxylation oxalyl chloride dicarboxylic acids alkylation superbasic medium 1,2,4-oxadiazoles spiropyrazolinium compounds in vitro antitubercular screening X-ray diffraction molecular docking polynuclear silver crystal structure pyrazolate ligand coordination polymer functionalization heterocyclic neurodegeneration Alzheimer’s disease Parkinson’s disease inhibitor antagonist antitumor scaffold enzymatic inhibitory N-heterocyclic compounds pyrazolo[1,5-a]pyrimidine pyrazolo[1,5-a]pyrimidines aromatic substitution electrooxidation C–H halogenation C–H thiocyanation N–N coupling cyclic voltammetry n/a
Acesso em linha:	https://directory.doabooks.org/handle/20.500.12854/93749
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Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I

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