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Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy

In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibit...

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Korporace:	Kwok, Hang Fai, Shaw, Christopher, Walker, Brian
Médium:	Livro
Jazyk:	Inglês
Vydáno:	MDPI - Multidisciplinary Digital Publishing Institute 2021
Témata:	thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general MMP MMP2 MMP9 MMP7 MMP14 matrix metalloproteases PDAC pancreatic cancer Bowman–Birk inhibitor ranacyclin trypsin inhibitor structure–activity relationship synergistic effect Gentamicin matrix metalloproteinase extracellular matrix nuclei cancer apoptosis immune response cysteine protease inhibitor stefin signal peptide parasite phylogenetic analysis diversification protein structure vascular endothelial growth factors (VEGFs) VEGF-A PlGF VEGF-B VEGF-C VEGF-D angiogenesis lymphangiogenesis CCBE1 proteases ADAMTS3 plasmin cathepsin D KLK3 prostate-specific antigen (PSA) thrombin wound healing metastasis proteolytic activation vascular biology lymphedema
On-line přístup:	https://directory.doabooks.org/handle/20.500.12854/77096
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Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy

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