Genomics and Models of Nerve Sheath Tumors

Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST)....

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Autor corporatiu: Hirbe, Angela C., Pratilas, Christine A., Dodd, Rebecca D.
Format: Livro
Idioma:Inglês
Publicat: MDPI - Multidisciplinary Digital Publishing Institute 2020
Matèries:
bic Book Industry Communication::M Medicine
neurofibromatosis type 1
nerve sheath tumor
cancer
latent variables
machine learning
supervised learning
transfer learning
random forest
metaVIPER
tumor deconvolution
neurofibromatosis
malignant peripheral nerve sheath tumor
MPNST
polycomb repressive complex
PRC2
NF1
kinase
kinome adaptation
kinome reprogramming
MET
MEK
doxorubicin
capmatinib
tram
genomics
tumor evolution
pathology
next generation sequencing
clinical genetics
malignant peripheral nerve sheath tumors
plexiform neurofibromas
Schwann cells
neurofibromatosis type 1 syndrome
neurofibromin 1
genetically engineered mouse models
heterogeneity
CRISPR/Cas9
mouse models
sarcoma
tumor microenvironment
neurofibromatosis 1 (NF1)
mebendazole (MBZ)
COX-2 inhibitor
malignancy
chemoprevention
nerve sheath tumors
Accés en línia:https://directory.doabooks.org/handle/20.500.12854/69300
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