Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Frontiers Research Topics
Main Authors: Stefano Morotti, Eleonora Grandi, Esther Pueyo, Blanca Rodriguez
פורמט: Livro
שפה:Inglês
יצא לאור: Frontiers Media SA 2018
נושאים:
QP1-981
Q1-390
thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
cardiotoxicity
cardiac electrophysiology.
drug-induced arrhythmia
QT interval prolongation
multi-scale modeling
גישה מקוונת:https://directory.doabooks.org/handle/20.500.12854/58773
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