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Kinase Inhibitor for Cancer Therapy

Cancer is one of the leading causes of death worldwide, yet considerable efforts are still required to make this pathology curable. Despite the limits of available approaches, kinase inhibitors have marked a turning point in the treatment of different types of tumors. This class of compounds is the...

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Detalhes bibliográficos
Autor Corporativo:	Musumeci, Francesca
Formato:	Livro
Idioma:	Inglês
Publicado em:	MDPI - Multidisciplinary Digital Publishing Institute 2024
Assuntos:	thema EDItEUR::P Mathematics and Science thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology JAK synthesis kinase inhibitory activity pharmacological uses binding mode/interactions choline kinase lipid metabolism cisplatin lung tumors combinatorial chemotherapy glioblastoma Src pyrazolo [3,4-d]pyrimidine scaffold EGFR multiple myeloma tyrosine kinase treatment ibrutinib gastric cancer kinase inhibitor ALK targeted therapy JNK3 fragment saturation transfer difference NMR X-ray crystallography breast cancer nanomedicine PI3K? poloxamers polymeric nanoparticles TPGS zanubrutinib anthracycline drug resistance aldo-keto reductase 1C3 ABC drug efflux transporter Hsp90 inhibitor co-chaperone heterocycle molecules anticancer agents heat shock proteins ER stress PERK UPR kinase inhibitor cancer diabetes small molecule structure–activity-relationship (SAR) MCL ROR1 small molecules apoptosis AKT1 kinase inhibitors acute myeloid leukemia rare disease molecular modeling molecular docking similarity search MD simulation computer-aided drug discovery cutaneous T-cell lymphoma TWIST1 erufosine curcumin synergy nanotechnology 3D tissue culture 3D tumor model tumor spheroids drug screening preclinical study tyrosine kinase inhibitors innate immunity thyroid cancer tumor-associated macrophages cytokines c-Src/Abl dual inhibitors pyrazolo[3,4-d]pyrimidines ADME antiproliferative activity childhood cancer kinases chemical inhibitors clinical trials dasatinib CML HIV-1 CMV HIV functional cure memory-like NK cells ?? T cells anti-aging senolytic NSCLC KAN0441571C erlotinib TTP rigosertib ON-01910.Na cancer therapy kinase allosteric inhibition Plk1 Ras JNK PI3K/Akt microtubule-destabilizing agents stress-signaling pathways aptamer MNK1 therapeutic target non-small cell lung cancer antitumor 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine (DMAT) derivatives protein kinase CK2 protein kinase PIM-1 dual protein kinase inhibitors antitumor activity autophagy hepatocellular carcinoma EGFR/PI3K/AKT/mTOR signaling animal models n/a
Acesso em linha:	https://directory.doabooks.org/handle/20.500.12854/139351
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Kinase Inhibitor for Cancer Therapy

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