MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons

Por Fuller, Abby D., Van Eldik, Linda J.
Publicado em 2008

The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS

Por Bachstetter, Adam D., Van Eldik, Linda J.
Publicado em 2010

Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Δ(12,14)-prostaglandin J(2)

Por Petrova, Tatiana V., Akama, Keith T., Van Eldik, Linda J.
Publicado em 1999

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

Por Xing, Bin, Bachstetter, Adam D, Van Eldik, Linda J
Publicado em 2011

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

Por Xing, Bin, Bachstetter, Adam D., Van Eldik, Linda J.
Publicado em 2013

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

Por Bachstetter, Adam D, Xing, Bin, Van Eldik, Linda J
Publicado em 2014

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults

Por Xing, Bin, Bachstetter, Adam D., Van Eldik, Linda J.
Publicado no J Mol Neurosci (2014)

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

Por Thompson, Wendy L, Karpus, William J, Van Eldik, Linda J
Publicado em 2008

Targeting protein kinases in central nervous system disorders

Por Chico, Laura K., Van Eldik, Linda J., Watterson, D. Martin
Publicado em 2009

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

Por Webster, Scott J, Bachstetter, Adam D, Van Eldik, Linda J
Publicado em 2013

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

Por Bachstetter, Adam D., Watterson, D. Martin, Van Eldik, Linda J.
Publicado em 2014

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism

Por Akama, Keith T., Albanese, Chris, Pestell, Richard G., Van Eldik, Linda J.
Publicado em 1998

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid

Por Craft, Jeffrey M, Watterson, D Martin, Hirsch, Emmet, Van Eldik, Linda J
Publicado em 2005

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target

Por Borders, Aaron S, de Almeida, Lucia, Van Eldik, Linda J, Watterson, D Martin
Publicado em 2008

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of th...

Por Bachstetter, Adam D, Webster, Scott J, Van Eldik, Linda J, Cambi, Franca
Publicado em 2013

Closed Head Injury in an Age-Related Alzheimer Mouse Model Leads to an Altered Neuroinflammatory Response and Persistent Cognitive Impairment

Por Webster, Scott J., Van Eldik, Linda J., Watterson, D. Martin, Bachstetter, Adam D.
Publicado no J Neurosci (2015)

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse mo...

Por Lloyd, Eric, Somera-Molina, Kathleen, Van Eldik, Linda J, Watterson, D Martin, Wainwright, Mark S
Publicado em 2008

Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug

Por Karpus, William J., Reynolds, Nathaneal, Behanna, Heather A., Van Eldik, Linda J., Watterson, D. Martin
Publicado em 2008

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model

Por Somera-Molina, Kathleen C., Nair, Sangeetha, Van Eldik, Linda J., Watterson, D. Martin, Wainwright, Mark S.
Publicado em 2009

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

Por Webster, Scott J., Bachstetter, Adam D., Nelson, Peter T., Schmitt, Frederick A., Van Eldik, Linda J.
Publicado em 2014