Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

par Robertson, Naomi S., Spring, David R.
Publié dans Molecules (2018)

Rational Methods for the Selection of Diverse Screening Compounds

par Huggins, David J., Venkitaraman, Ashok R., Spring, David R.
Publié dans ACS Chem Biol (2011)

Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489

par Geddis, Stephen M., Carro, Laura, Hodgkinson, James T., Spring, David R.
Publié dans European J Org Chem (2016)

Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

par Charoenpattarapreeda, Jiraborrirak, Walsh, Stephen J., Carroll, Jason S., Spring, David R.
Publié dans Angew Chem Int Ed Engl (2020)

A new Pseudomonas quinolone signal (PQS) binding partner: MexG

par Hodgkinson, James T., Gross, Jeremy, Baker, Ysobel R., Spring, David R., Welch, M.
Publié dans Chem Sci (2016)

Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol

par Knighton, Richard C., Sharma, Krishna, Robertson, Naomi S., Spring, David R., Wills, Martin
Publié dans ACS Omega (2019)

A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium

par Ramsay, Joshua P., Williamson, Neil R., Spring, David R., Salmond, George P. C.
Publié 2011

Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe

par Liu, Tianyu, Liu, Xiaogang, Spring, David R., Qian, Xuhong, Cui, Jingnan, Xu, Zhaochao
Publié 2014

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence

par Wiedmann, Mareike M., Aibara, Shintaro, Spring, David R., Stewart, Murray, Brenton, James D.
Publié dans J Struct Biol (2016)

Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin

par Baker, Ysobel R., Galloway, Warren R. J. D., Hodgkinson, James T., Spring, David R.
Publié dans Molecules (2013)

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

par Laraia, Luca, McKenzie, Grahame, Spring, David R., Venkitaraman, Ashok R., Huggins, David J.
Publié dans Chem Biol (2015)

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

par Kidd, Sarah L., Osberger, Thomas J., Mateu, Natalia, Sore, Hannah F., Spring, David R.
Publié dans Front Chem (2018)

Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products

par Geddis, Stephen M, Coroama, Teodora, Forrest, Suzanne, Hodgkinson, James T, Welch, Martin, Spring, David R
Publié dans Beilstein J Org Chem (2018)

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule

par Hodgkinson, James, Bowden, Steven D., Galloway, Warren R. J. D., Spring, David R., Welch, Martin
Publié 2010

Stereocontrolled semi-syntheses of deguelin and tephrosin

par Russell, David A., Freudenreich, Julien J., Ciardiello, Joe J., Sore, Hannah F., Spring, David R.
Publié dans Org Biomol Chem (2017)

Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes

par Guarnieri-Ibáñez, Alejandro, Medina, Florian, Besnard, Céline, Kidd, Sarah L., Spring, David R., Lacour, Jérôme
Publié dans Chem Sci (2017)

Rapid and robust cysteine bioconjugation with vinylheteroarenes

par Seki, Hikaru, Walsh, Stephen J., Bargh, Jonathan D., Parker, Jeremy S., Carroll, Jason, Spring, David R.
Publié dans Chem Sci (2021)

Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

par O’Connell, Kieron M G, Díaz-Gavilán, Monica, Galloway, Warren R J D, Spring, David R
Publié 2012

High Content Screening of Diverse Compound Libraries Identifies Potent Modulators of Tubulin Dynamics

par Laraia, Luca, Stokes, Jamie, Emery, Amy, McKenzie, Grahame J., Venkitaraman, Ashok R., Spring, David R.
Publié 2014

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

par Atkinson, Eleanor L., Iegre, Jessica, Brear, Paul D., Zhabina, Elizabeth A., Hyvönen, Marko, Spring, David R.
Publié dans Molecules (2021)