Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

by Robertson, Naomi S., Spring, David R.
Published in Molecules (2018)

Rational Methods for the Selection of Diverse Screening Compounds

by Huggins, David J., Venkitaraman, Ashok R., Spring, David R.
Published in ACS Chem Biol (2011)

Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489

by Geddis, Stephen M., Carro, Laura, Hodgkinson, James T., Spring, David R.
Published in European J Org Chem (2016)

Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

by Charoenpattarapreeda, Jiraborrirak, Walsh, Stephen J., Carroll, Jason S., Spring, David R.
Published in Angew Chem Int Ed Engl (2020)

A new Pseudomonas quinolone signal (PQS) binding partner: MexG

by Hodgkinson, James T., Gross, Jeremy, Baker, Ysobel R., Spring, David R., Welch, M.
Published in Chem Sci (2016)

Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol

by Knighton, Richard C., Sharma, Krishna, Robertson, Naomi S., Spring, David R., Wills, Martin
Published in ACS Omega (2019)

A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium

by Ramsay, Joshua P., Williamson, Neil R., Spring, David R., Salmond, George P. C.
Published 2011

Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe

by Liu, Tianyu, Liu, Xiaogang, Spring, David R., Qian, Xuhong, Cui, Jingnan, Xu, Zhaochao
Published 2014

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence

by Wiedmann, Mareike M., Aibara, Shintaro, Spring, David R., Stewart, Murray, Brenton, James D.
Published in J Struct Biol (2016)

Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin

by Baker, Ysobel R., Galloway, Warren R. J. D., Hodgkinson, James T., Spring, David R.
Published in Molecules (2013)

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

by Laraia, Luca, McKenzie, Grahame, Spring, David R., Venkitaraman, Ashok R., Huggins, David J.
Published in Chem Biol (2015)

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

by Kidd, Sarah L., Osberger, Thomas J., Mateu, Natalia, Sore, Hannah F., Spring, David R.
Published in Front Chem (2018)

Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products

by Geddis, Stephen M, Coroama, Teodora, Forrest, Suzanne, Hodgkinson, James T, Welch, Martin, Spring, David R
Published in Beilstein J Org Chem (2018)

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule

by Hodgkinson, James, Bowden, Steven D., Galloway, Warren R. J. D., Spring, David R., Welch, Martin
Published 2010

Stereocontrolled semi-syntheses of deguelin and tephrosin

by Russell, David A., Freudenreich, Julien J., Ciardiello, Joe J., Sore, Hannah F., Spring, David R.
Published in Org Biomol Chem (2017)

Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes

by Guarnieri-Ibáñez, Alejandro, Medina, Florian, Besnard, Céline, Kidd, Sarah L., Spring, David R., Lacour, Jérôme
Published in Chem Sci (2017)

Rapid and robust cysteine bioconjugation with vinylheteroarenes

by Seki, Hikaru, Walsh, Stephen J., Bargh, Jonathan D., Parker, Jeremy S., Carroll, Jason, Spring, David R.
Published in Chem Sci (2021)

Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

by O’Connell, Kieron M G, Díaz-Gavilán, Monica, Galloway, Warren R J D, Spring, David R
Published 2012

High Content Screening of Diverse Compound Libraries Identifies Potent Modulators of Tubulin Dynamics

by Laraia, Luca, Stokes, Jamie, Emery, Amy, McKenzie, Grahame J., Venkitaraman, Ashok R., Spring, David R.
Published 2014

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

by Atkinson, Eleanor L., Iegre, Jessica, Brear, Paul D., Zhabina, Elizabeth A., Hyvönen, Marko, Spring, David R.
Published in Molecules (2021)