Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas

Por Siempelkamp, Braden D., Rathinaswamy, Manoj K., Jenkins, Meredith L., Burke, John E.
Publicado no J Biol Chem (2017)

Conformational sampling of membranes by Akt controls its activation and inactivation

Por Lučić, Iva, Rathinaswamy, Manoj K., Truebestein, Linda, Hamelin, David J., Burke, John E., Leonard, Thomas A.
Publicado no Proc Natl Acad Sci U S A (2018)

Ras Binder Induces a Modified Switch-II Pocket in GTP- and GDP-States

Por Gentile, Daniel R., Rathinaswamy, Manoj K., Jenkins, Meredith L., Moss, Steven M., Siempelkamp, Braden D., Renslo, Adam R., Burke, John E., Shokat, Kevan M.
Publicado no Cell Chem Biol (2017)