Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C.

af Pyne, S, Pyne, N J
Udgivet 1995

Sphingosine 1-phosphate signalling in mammalian cells.

af Pyne, S, Pyne, N J
Udgivet 2000

The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth mus...

af Pyne, S, Pyne, N J
Udgivet 1996

Differential effects of B2 receptor antagonists upon bradykinin-stimulated phospholipase C and D in guinea-pig cultured tracheal smooth muscle.

af Pyne, S., Pyne, N. J.
Udgivet 1993

Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C.

af Pyne, N J, Freissmuth, M, Palmer, S
Udgivet 1992

Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.

af Pyne, N J, Tolan, D, Pyne, S
Udgivet 1997

The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung.

af Burns, F, Rodger, I W, Pyne, N J
Udgivet 1992

Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyro...

af Conway, A M, Rakhit, S, Pyne, S, Pyne, N J
Udgivet 1999

The identification of apparently novel cyclic AMP and cyclic GMP phosphodiesterase activities in guinea-pig tracheal smooth muscle.

af Burns, F, Stevens, P A, Pyne, N J
Udgivet 1994

Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways.

af Stevens, P A, Pyne, S, Grady, M, Pyne, N J
Udgivet 1994

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver.

af Pyne, N J, Cooper, M E, Houslay, M D
Udgivet 1986

The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity.

af Pyne, N J, Cooper, M E, Houslay, M D
Udgivet 1987

Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.

af Shafiee-Nick, R., Pyne, N. J., Furman, B. L.
Udgivet 1995

Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) a...

af Pyne, N J, Moughal, N, Stevens, P A, Tolan, D, Pyne, S
Udgivet 1994

Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes.

af Pyne, N J, Cushley, W, Nimmo, H G, Houslay, M D
Udgivet 1989

Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.

af Moughal, N, Stevens, P A, Kong, D, Pyne, S, Pyne, N J
Udgivet 1995

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kina...

af Rakhit, S, Conway, A M, Tate, R, Bower, T, Pyne, N J, Pyne, S
Udgivet 1999

The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle.

af Tolan, D., Conway, A. M., Steele, L., Pyne, S., Pyne, N. J.
Udgivet 1996

Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi).

af Pyne, N. J., Grady, M. W., Shehnaz, D., Stevens, P. A., Pyne, S., Rodger, I. W.
Udgivet 1992

Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases d...

af Pyne, N J, Anderson, N, Lavan, B E, Milligan, G, Nimmo, H G, Houslay, M D
Udgivet 1987