Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

Por Powley, Ian R., Patel, Meeta, Miles, Gareth, Pringle, Howard, Howells, Lynne, Thomas, Anne, Kettleborough, Catherine, Bryans, Justin, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin
Publicado no Br J Cancer (2020)

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Por Hughes, Michelle A., Powley, Ian R., Jukes-Jones, Rebekah, Horn, Sebastian, Feoktistova, Maria, Fairall, Louise, Schwabe, John W.R., Leverkus, Martin, Cain, Kelvin, MacFarlane, Marion
Publicado no Mol Cell (2016)

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

Por Fox, Joanna L., Hughes, Michelle A., Meng, Xin, Sarnowska, Nikola A., Powley, Ian R., Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J., Fairall, Louise, Schwabe, John W. R., Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion
Publicado no Nat Commun (2021)

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes

Por Powley, Ian R., Kondrashov, Alexander, Young, Lucy A., Dobbyn, Helen C., Hill, Kirsti, Cannell, Ian G., Stoneley, Mark, Kong, Yi-Wen, Cotes, Julia A., Smith, Graeme C.M., Wek, Ron, Hayes, Christopher, Gant, Timothy W., Spriggs, Keith A., Bushell, Martin, Willis, Anne E.
Publicado em 2009

Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)

Por Chernova, Tatyana, Murphy, Fiona A., Galavotti, Sara, Sun, Xiao-Ming, Powley, Ian R., Grosso, Stefano, Schinwald, Anja, Zacarias-Cabeza, Joaquin, Dudek, Kate M., Dinsdale, David, Le Quesne, John, Bennett, Jonathan, Nakas, Apostolos, Greaves, Peter, Poland, Craig A., Donaldson, Ken, Bushell, Martin, Willis, Anne E., MacFarlane, Marion
Publicado no Curr Biol (2017)