Series Introduction: The cellular response to aggregated proteins associated with human disease

por Perlmutter, David H.
Publicado 2002

Liver injury in α(1)-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

por Perlmutter, David H.
Publicado 2002

Current and Emerging Treatments for Alpha-1 Antitrypsin Deficiency

por Perlmutter, David H.
Publicado en Gastroenterol Hepatol (N Y) (2016)

α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum

por Perlmutter, David H
Publicado en Endoplasmic Reticulum Stress Dis (2016)

Washington University: Research, Education, and Innovative Health Care

por Perlmutter, David H.
Publicado en Mo Med (2019)

Novel Treatment Strategies for Liver Disease Due to a1‐Antitrypsin Deficiency

por Maurice, Nicholas, Perlmutter, David H.
Publicado 2012

Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency

por Wang, Yan, Perlmutter, David H.
Publicado 2013

Hepatic Fibrosis and Carcinogenesis in α1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders

por Perlmutter, David H., Silverman, Gary A.
Publicado 2011

Capitalizing on the Autophagic Response for Treatment of Liver Disease Caused by Alpha-1-Antitrypsin Deficiency and Other Genetic Diseases

por Chu, Andrew S., Perlmutter, David H., Wang, Yan
Publicado 2014

Two new considerations for improving the diagnosis of α1-antitrypsin deficiency-associated liver disease

por Perlmutter, David H, Chopra, Kapil, Chu, Andrew
Publicado en Dig Dis Sci (2015)

Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration

por Rudnick, David A., Perlmutter, David H., Muglia, Louis J.
Publicado 2001

Disorders of Protein Misfolding: Alpha-1-antitrypsin Deficiency as Prototype

por Silverman, Gary A., Pak, Stephen C., Perlmutter, David H.
Publicado 2013

Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease

por Ghouse, Raafe, Chu, Andrew, Wang, Yan, Perlmutter, David H.
Publicado 2014

Chemical chaperones mediate increased secretion of mutant α1-antitrypsin (α1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in α1-AT defic...

por Burrows, Jon A. J., Willis, Lauren K., Perlmutter, David H.
Publicado 2000

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

por Gregory, Alyssa D., Hale, Pamela, Perlmutter, David H., Houghton, A. McGarry
Publicado 2012

α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery

por O’Reilly, Linda P., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Publicado 2013

NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms

por Mukherjee, Amitava, Hidvegi, Tunda, Araya, Patrick, Ewing, Michael, Stolz, Donna B., Perlmutter, David H.
Publicado en Cell Death Differ (2018)

The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking α-1 Antitrypsin

por Gelling, Cristy L., Dawes, Ian W., Perlmutter, David H., Fisher, Edward A., Brodsky, Jeffrey L.
Publicado 2012

C. elegans in high-throughput drug discovery

por O’Reilly, Linda P., Luke, Cliff J., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Publicado 2013

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

por Shi, Qingya, Pei, Fen, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Liu, Bing, Bahar, Ivet
Publicado en Int J Mol Sci (2020)