Series Introduction: The cellular response to aggregated proteins associated with human disease

by Perlmutter, David H.
Published 2002

Liver injury in α(1)-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

by Perlmutter, David H.
Published 2002

Current and Emerging Treatments for Alpha-1 Antitrypsin Deficiency

by Perlmutter, David H.
Published in Gastroenterol Hepatol (N Y) (2016)

α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum

by Perlmutter, David H
Published in Endoplasmic Reticulum Stress Dis (2016)

Washington University: Research, Education, and Innovative Health Care

by Perlmutter, David H.
Published in Mo Med (2019)

Novel Treatment Strategies for Liver Disease Due to a1‐Antitrypsin Deficiency

by Maurice, Nicholas, Perlmutter, David H.
Published 2012

Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency

by Wang, Yan, Perlmutter, David H.
Published 2013

Hepatic Fibrosis and Carcinogenesis in α1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders

by Perlmutter, David H., Silverman, Gary A.
Published 2011

Capitalizing on the Autophagic Response for Treatment of Liver Disease Caused by Alpha-1-Antitrypsin Deficiency and Other Genetic Diseases

by Chu, Andrew S., Perlmutter, David H., Wang, Yan
Published 2014

Two new considerations for improving the diagnosis of α1-antitrypsin deficiency-associated liver disease

by Perlmutter, David H, Chopra, Kapil, Chu, Andrew
Published in Dig Dis Sci (2015)

Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration

by Rudnick, David A., Perlmutter, David H., Muglia, Louis J.
Published 2001

Disorders of Protein Misfolding: Alpha-1-antitrypsin Deficiency as Prototype

by Silverman, Gary A., Pak, Stephen C., Perlmutter, David H.
Published 2013

Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease

by Ghouse, Raafe, Chu, Andrew, Wang, Yan, Perlmutter, David H.
Published 2014

Chemical chaperones mediate increased secretion of mutant α1-antitrypsin (α1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in α1-AT defic...

by Burrows, Jon A. J., Willis, Lauren K., Perlmutter, David H.
Published 2000

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

by Gregory, Alyssa D., Hale, Pamela, Perlmutter, David H., Houghton, A. McGarry
Published 2012

α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery

by O’Reilly, Linda P., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Published 2013

NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms

by Mukherjee, Amitava, Hidvegi, Tunda, Araya, Patrick, Ewing, Michael, Stolz, Donna B., Perlmutter, David H.
Published in Cell Death Differ (2018)

The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking α-1 Antitrypsin

by Gelling, Cristy L., Dawes, Ian W., Perlmutter, David H., Fisher, Edward A., Brodsky, Jeffrey L.
Published 2012

C. elegans in high-throughput drug discovery

by O’Reilly, Linda P., Luke, Cliff J., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Published 2013

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

by Shi, Qingya, Pei, Fen, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Liu, Bing, Bahar, Ivet
Published in Int J Mol Sci (2020)