Series Introduction: The cellular response to aggregated proteins associated with human disease

Autor Perlmutter, David H.
Vydáno 2002

Liver injury in α(1)-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

Autor Perlmutter, David H.
Vydáno 2002

Current and Emerging Treatments for Alpha-1 Antitrypsin Deficiency

Autor Perlmutter, David H.
Vydáno v Gastroenterol Hepatol (N Y) (2016)

α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum

Autor Perlmutter, David H
Vydáno v Endoplasmic Reticulum Stress Dis (2016)

Washington University: Research, Education, and Innovative Health Care

Autor Perlmutter, David H.
Vydáno v Mo Med (2019)

Novel Treatment Strategies for Liver Disease Due to a1‐Antitrypsin Deficiency

Autor Maurice, Nicholas, Perlmutter, David H.
Vydáno 2012

Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency

Autor Wang, Yan, Perlmutter, David H.
Vydáno 2013

Hepatic Fibrosis and Carcinogenesis in α1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders

Autor Perlmutter, David H., Silverman, Gary A.
Vydáno 2011

Capitalizing on the Autophagic Response for Treatment of Liver Disease Caused by Alpha-1-Antitrypsin Deficiency and Other Genetic Diseases

Autor Chu, Andrew S., Perlmutter, David H., Wang, Yan
Vydáno 2014

Two new considerations for improving the diagnosis of α1-antitrypsin deficiency-associated liver disease

Autor Perlmutter, David H, Chopra, Kapil, Chu, Andrew
Vydáno v Dig Dis Sci (2015)

Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration

Autor Rudnick, David A., Perlmutter, David H., Muglia, Louis J.
Vydáno 2001

Disorders of Protein Misfolding: Alpha-1-antitrypsin Deficiency as Prototype

Autor Silverman, Gary A., Pak, Stephen C., Perlmutter, David H.
Vydáno 2013

Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease

Autor Ghouse, Raafe, Chu, Andrew, Wang, Yan, Perlmutter, David H.
Vydáno 2014

Chemical chaperones mediate increased secretion of mutant α1-antitrypsin (α1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in α1-AT defic...

Autor Burrows, Jon A. J., Willis, Lauren K., Perlmutter, David H.
Vydáno 2000

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

Autor Gregory, Alyssa D., Hale, Pamela, Perlmutter, David H., Houghton, A. McGarry
Vydáno 2012

α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery

Autor O’Reilly, Linda P., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Vydáno 2013

NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms

Autor Mukherjee, Amitava, Hidvegi, Tunda, Araya, Patrick, Ewing, Michael, Stolz, Donna B., Perlmutter, David H.
Vydáno v Cell Death Differ (2018)

The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking α-1 Antitrypsin

Autor Gelling, Cristy L., Dawes, Ian W., Perlmutter, David H., Fisher, Edward A., Brodsky, Jeffrey L.
Vydáno 2012

C. elegans in high-throughput drug discovery

Autor O’Reilly, Linda P., Luke, Cliff J., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Vydáno 2013

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Autor Shi, Qingya, Pei, Fen, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Liu, Bing, Bahar, Ivet
Vydáno v Int J Mol Sci (2020)