AMPK ATGs Autophagy Beclin-1 COPD Crohn’s disease FOXO HCC therapy LC3 MTOR Notoginsenoside R1 PAH PINK1 Paneth cell Parkin Sertoli cell TFEB acute kidney injury acute lung injury aging apoptosis autophagic flux autophagy bic Book Industry Communication::M Medicine biomarkers caloric restriction cardiac dysfunction cell death cirrhosis cystic fibrosis