Pluripotent stem cells for pathological modelling of Hutchinson-Gilford Progeria Syndrome (HGPS) and drug discovery

Por Nissan, Xavier
Publicado no Orphanet J Rare Dis (2015)

Functional melanocytes derived from human pluripotent stem cells engraft into pluristratified epidermis

Por Nissan, Xavier, Larribere, Lionel, Saidani, Manoubia, Hurbain, Ilse, Delevoye, Cédric, Feteira, Jessica, Lemaitre, Gilles, Peschanski, Marc, Baldeschi, Christine
Publicado em 2011

MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

Por Harhouri, Karim, Navarro, Claire, Depetris, Danielle, Mattei, Marie‐Geneviève, Nissan, Xavier, Cau, Pierre, De Sandre‐Giovannoli, Annachiara, Lévy, Nicolas
Publicado no EMBO Mol Med (2017)

Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells

Por Egesipe, Anne-Laure, Blondel, Sophie, Lo Cicero, Alessandra, Jaskowiak, Anne-Laure, Navarro, Claire, Sandre-Giovannoli, Annachiara De, Levy, Nicolas, Peschanski, Marc, Nissan, Xavier
Publicado no NPJ Aging Mech Dis (2016)

Biomechanical strain exacerbates inflammation on a progeria-on-a-chip model

Por Ribas, João, Zhang, Yu Shrike, Pitrez, Patrícia R., Leijten, Jeroen, Miscuglio, Mario, Rouwkema, Jeroen, Dokmeci, Mehmet Remzi, Nissan, Xavier, Ferreira, Lino, Khademhosseini, Ali
Publicado no Small (2017)

A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells

Por Lo Cicero, Alessandra, Jaskowiak, Anne-Laure, Egesipe, Anne-Laure, Tournois, Johana, Brinon, Benjamin, Pitrez, Patricia R., Ferreira, Lino, de Sandre-Giovannoli, Annachiara, Levy, Nicolas, Nissan, Xavier
Publicado no Sci Rep (2016)

Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes

Por Lo Cicero, Alessandra, Saidani, Manoubia, Allouche, Jennifer, Egesipe, Anne Laure, Hoch, Lucile, Bruge, Celine, Sigaudy, Sabine, De Sandre-Giovannoli, Annachiara, Levy, Nicolas, Baldeschi, Christine, Nissan, Xavier
Publicado no Sci Rep (2018)

In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells

Por Allouche, Jennifer, Bellon, Nathalia, Saidani, Manoubia, Stanchina-Chatrousse, Laure, Masson, Yolande, Patwardhan, Anand, Gilles-Marsens, Floriane, Delevoye, Cédric, Domingues, Sophie, Nissan, Xavier, Martinat, Cécile, Lemaitre, Gilles, Peschanski, Marc, Baldeschi, Christine
Publicado no Proc Natl Acad Sci U S A (2015)

Induced Pluripotent Stem Cells Reveal Functional Differences Between Drugs Currently Investigated in Patients With Hutchinson-Gilford Progeria Syndrome

Por Blondel, Sophie, Jaskowiak, Anne-Laure, Egesipe, Anne-Laure, Le Corf, Amelie, Navarro, Claire, Cordette, Véronique, Martinat, Cécile, Laabi, Yacine, Djabali, Karima, de Sandre-Giovannoli, Annachiara, Levy, Nicolas, Peschanski, Marc, Nissan, Xavier
Publicado em 2014

In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin

Por Laustriat, Delphine, Gide, Jacqueline, Barrault, Laetitia, Chautard, Emilie, Benoit, Clara, Auboeuf, Didier, Boland, Anne, Battail, Christophe, Artiguenave, François, Deleuze, Jean-François, Bénit, Paule, Rustin, Pierre, Franc, Sylvia, Charpentier, Guillaume, Furling, Denis, Bassez, Guillaume, Nissan, Xavier, Martinat, Cécile, Peschanski, Marc, Baghdoyan, Sandrine
Publicado no Mol Ther Nucleic Acids (2015)