Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases

gan Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.
Cyhoeddwyd yn Angew Chem Weinheim Bergstr Ger (2016)

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases

gan Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.
Cyhoeddwyd yn Angew Chem Int Ed Engl (2016)

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

gan Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, White, Mark D., Ní Cheallaigh, Aisling, Balaikaite, Arune, Rigby, Stephen E. J., Leys, David
Cyhoeddwyd yn Nat Commun (2019)

Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis

gan Marshall, Stephen A., Fisher, Karl, Ní Cheallaigh, Aisling, White, Mark D., Payne, Karl A. P., Parker, D. A., Rigby, Stephen E. J., Leys, David
Cyhoeddwyd yn J Biol Chem (2017)

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase

gan Karuppiah, Vijaykumar, Ranaghan, Kara E., Leferink, Nicole G. H., Johannissen, Linus O., Shanmugam, Muralidharan, Ní Cheallaigh, Aisling, Bennett, Nathan J., Kearsey, Lewis J., Takano, Eriko, Gardiner, John M., van der Kamp, Marc W., Hay, Sam, Mulholland, Adrian J., Leys, David, Scrutton, Nigel S.
Cyhoeddwyd yn ACS Catal (2017)