FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organizat...

Por Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George
Publicado no EBioMedicine (2016)

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gen...

Por Ventura, Richard, Mordec, Kasia, Waszczuk, Joanna, Wang, Zhaoti, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George, Heuer, Timothy S.
Publicado no EBioMedicine (2015)

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Por Nichols, Robert J., Haderk, Franziska, Stahlhut, Carlos, Schulze, Christopher J., Hemmati, Golzar, Wildes, David, Tzitzilonis, Christos, Mordec, Kasia, Marquez, Abby, Romero, Jason, Hsieh, Tientien, Zaman, Aubhishek, Olivas, Victor, McCoach, Caroline, Blakely, Collin M., Wang, Zhengping, Kiss, Gert, Koltun, Elena S., Gill, Adrian L., Singh, Mallika, Goldsmith, Mark A., Smith, Jacqueline A. M., Bivona, Trever G.
Publicado no Nat Cell Biol (2018)