Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates

Por Mullins, Nicholas D., Maguire, Nuala M., Ford, Alan, Das, Kalyan, Arnold, Edward, Balzarini, Jan, Maguire, Anita R.
Publicado no Org Biomol Chem (2016)

Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses...

Por Balzarini, Jan, Menni, Michael, Das, Kalyan, van Berckelaer, Lizette, Ford, Alan, Maguire, Nuala M., Liekens, Sandra, Boehmer, Paul E., Arnold, Eddy, Götte, Matthias, Maguire, Anita R.
Publicado no Biochem Pharmacol (2017)