DMFt MIO Matrigel Myogel OCSCC University of Washington Quality of Life Questionnaire adjuvant therapy anxiety cell trajectory inference chemotherapy dental caries depression drug discovery esophageal cancer esophagectomy fibula free flap flap reconstruction free fibula flap functional outcome gender distribution head and neck head and neck cancer head and neck squamous cell carcinoma immunosuppression insomnia interincisal opening jaw mandibular reconstruction mandibulectomy meta-analysis